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Adolphe Merkle Institute

BioNanomaterials Group

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3D Tissue Models to Assess Hazards (Lung / Intestine / Skin)

Tissue-based 3D cell culture models mimic physiological and barrier properties of human skin, lung or…

 

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Adhesion in Cytoskeleton Dynamics

Adhesion in Cytoskeleton Dynamics

 

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AirTox Monitor: online measurement approach to monitor particles on cells

Developing a platform for the non-invasive and real-time monitoring of carbon-based particles during…

 

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Bio-inspired Agrochemicals

We use the agricultural legume crop Medicago sativa (alfalfa) to characterize the efficiency and biological…

 

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Bioinspired Hyaluronic Acid-coated Gold Nanoparticles to Target Lung Cancer Cells

Hyaluronic acid coated gold nanoparticles with Doxorubicin

 

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Biomedical Nanoparticles

Enzyme-containing nanoparticles as reactive oxygen species (ROS) scavengers are promising drug candidates…

 

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Bioprinting of Tissue / Spheorids

3D bioprinting as an innovative approach for tissue engineering.

 

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Detection of volatile organic compound (VOC) emission biomarkers for human lung cells

Establishing the VOC emission biomarker database of human lung tissues under culture and particle-induced…

 

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Development of a Chronic Wound Skin Equivalent for Nanocarrier Testing

This project aims to develop a human skin equivalent model under both healthy and diabetic conditions.

 

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Dosimetry

Dosimetry

 

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Engineering Core-Shell Nanomaterials

Design of Safe Core-Shell Nanoparticles for Understanding Cellular Interactions

 

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Enzyme-catalyzed ATRP

Proteins such as hemoglobin, peroxidase or laccase are ATRPases, i.e. they catalyze ATRP

 

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Exploring Cell Density Effects on Nanoparticle Uptake Using Bioprinted Gradients

We aim to understand how density-driven changes in cell properties modulate NP interactions.

 

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Extraction and Detection of Nanoparticles

Extraction and Detection of Nanoparticles

 

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Hazard Assessment of Aerosolized Nanomaterials

Aerosolisation approaches for a direct and controlled exposure of nanomaterials on the cell surface

 

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Hybrid Nanomaterials

Design and fabrication of multifunctional nanocomposites.

 

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In Vitro Lung Co-Culture Model for Evaluating Therapeutic Treatments and Inflammatory Responses

In Vitro Lung Co-Culture Model for Evaluating Anti-Inflammatory Effects of Herbal Medicines

 

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In vitro particle dosimetry

Nanoparticle dosimetry and computational particle kinetic models for in vitro toxicology studies

 

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Incorporation of nanoparticles to tune the properties of epoxy polymeric materials.

Nanoparticles can be incorporated into polymeric materials to form a composite with unique properties.

 

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Investigation of combustion-derived particles' effects on human intestine tissue in-vitro.

Combustion-derived particles from transportation

 

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Light-responsive polymersome nanoreactors

Responsive polymersomes for drug production on demand or to release active compounds

 

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Lock-in Thermography

Lock-in Thermography

 

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Making Lung Models More Relevant for Safety Testing

Development of the alternative to animal testing

 

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Mechanoresponsive Cell Substrates

Mechanoresponsive Cell Substrates

 

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Microscopy in life and material sciences

State-of-the-art microscopy techniques for the characterisation and analysis of life science and material…

 

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Nanoencapsulation for Enhanced Oral Bioavailability of Vitamins

Developing cost-effective nano-carrier systems to improve beta-carotene delivery and effectiveness.

 

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NanoLockin

Detecting nanoparticles in complex media is all in a day's work for the first AMI startup

 

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Nanoparticle analytics at the bionano interface

Analyses of nanoparticles in complex fluids

 

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Nanoparticle Functionalization

Novel functionalization strategies for tailoring properties (optical, magnetic, heat …) of nanoparticles…

 

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Nanoparticle Synthesis

Synthetic strategies to fabricate a wide variety of nanoparticles with tight control of size, composition…

 

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Nanoparticles and Cell Mechanics

Nanoparticles and Cell Mechanics

 

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Nanoparticles for Wood Preservation

Nanoparticles are promising wood protecting agents. We investigate key parameters to improve their impregnation…

 

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Nanoplastic Analytics

Detection of nanoplastic in complex matrices by integrating different analytical techniques

 

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Nanoplastic-cell interactions: Spectroscopic analysis and potential toxicity

Detection and analysis of nanoplastics within eukaryotic cells utilizing spectroscopic techniques.

 

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Particle Stability and Stimuli-Responsiveness

Surface and intrinsic properties of nanomaterials can be exploited to trigger receptor-mediated uptake…

 

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Plastic Micro- and Nanoparticles

Preparation and characterization of micro- and nano-sized plastic particles for human hazard assessments.

 

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Plastic Micro- and Nanoparticles in Analytically Complex Environments

Develop standardized methods for the detection of plastic micro- and nanoparticles

 

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Self-Assembled Nanoparticles

Enhancement of applicability, versatility and physicochemical properties of nanoparticles through their…

 

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Smart surfaces for tissue engineering

This project explores how extracellular environments influence cell behavior in the context of tissue…

 

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Soil Plant Analytics

Soil Plant Analytics

 

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Stimulation of cellular endocytosis for sensing and enhancing nanoparticle uptake

With the development of nanotechnology, nanoparticles ...

 

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Surface-Enhanced Raman Spectroscopy for the detection of nanoplastics

Detection and quantification of nanoplastics in liquid samples using Surface enhanced Raman spectroscopy

 

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Swiss NanoAnalytics

Platform for analytical services and consulting

 

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Taylor Dispersion Analysis

Taylor Dispersion Analysis

 

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Tracking micro- & nanoplastic-induced cellular toxicity using label-free Raman microscopy

Assessing micro- & nanoplastic-induced toxicity at the molecular level.

 

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Trafficking of Nanomaterials

Uptake, intracellular trafficking, and exocytosis are processes that affect cytotoxicity, cell behavior,…

 

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Understanding the Velvet Worm Slime Curing Mechanism

Understanding the Velvet Worm Slime Curing Mechanism

 

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“from-surface” cellular uptake of nanoparticles

Study and engineer the “from-surface” cellular uptake of nanoparticles.

 

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