This project focuses on the development of a reproducible human omentum model using three-dimensional (3D) bioprinting technology, which allows spatially controlled deposition of cells and biomaterials in an automated process. We aim to mimic the defined structure of the human omentum and evaluate its capacity to simulate the in vivo condition both in healthy and diseased states. Additionally,visualization and characterization to investigate adhesion and migration property of cancer cells into this 3D human omentum tissue is envisaged.
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Collagen-rich omentum is a premetastatic niche for integrin α2-mediated peritoneal metastasis
Huang Yen-Lin, Liang Ching-Yeu, Ritz Danilo, Coelho Ricardo, Septiadi Dedy, Estermann Manuela, Cumin Cécile, Rimmer Natalie, Schötzau Andreas, Núñez López Mónica, Fedier André, Konantz Martina, Vlajnic Tatjana, Calabrese Diego, Lengerke Claudia, David Leonor, Rothen-Rutishauser Barbara, Jacob Francis, Heinzelmann-Schwarz Viola
eLife (2020)Patient-derived and artificial ascites have minor effects on MeT-5A mesothelial cells and do not facilitate ovarian cancer cell adhesion
Estermann Manuela, Huang Yen-Lin, Septiadi Dedy, Ritz Danilo, Liang Ching-Yeu, Jacob Francis, Drasler Barbara, Petri-Fink Alke, Heinzelmann-Schwarz Viola, Rothen-Rutishauser Barbara
PLOS ONE (2020)
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