Person | Adolphe Merkle Institute | Université de Fribourg

LEE Wangsik

BioNanomaterials

Adolphe Merkle Institute Chemin des Verdiers 4 CH-1700 Fribourg Switzerland

Office:	C214
Phone:	+41 26 300 9218
Email:	wangsik.lee@unifr.ch
	0009-0000-6512-4133

Projects lead

Engineering Core-Shell Nanomaterials

Design of Safe Core-Shell Nanoparticles for Understanding Cellular Interactions

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Projects team

Exploring Cell Density Effects on Nanoparticle Uptake Using Bioprinted Gradients

We aim to understand how density-driven changes in cell properties modulate NP interactions.

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Publications

The impact of cell density variations on nanoparticle uptake across bioprinted A549 gradients
Luigi Di Stolfo, Wang Sik Lee, Dimitri Vanhecke, Sandor Balog, Patricia Taladriz-Blanco, Alke Petri-Fink, Barbara Rothen-Rutishauser
Frontiers in Bioengineering and Biotechnology 13 (2025)

Type-dependent effects of nanoplastics on microglial activation and CXCR2-mediated chemotactic migration
Jahong Koo, Bohyeon Jeong, Jeong Yeob Baek, Wang Sik Lee, Jiyoung Gong, Subin Park, Jiyeon Hong, Yugyeong Sim, Dae Soo Kim, Sang Ryong Kim, Jinyoung Jeong, Da Yong Lee
Nanoscale 17 , 17274-17284 (2025)

Maternal nanoplastic ingestion induces an increase in offspring body weight through altered lipid species and microbiota
Bohyeon Jeong, Ji-Sun Kim, A Ra Kwon, Jangjae Lee, Subin Park, Jahong Koo, Wang Sik Lee, Jeong Yeob Baek, Won-Ho Shin, Jung-Sook Lee, Jinyoung Jeong, Won Kon Kim, Cho-Rok Jung, Nam-Soon Kim, Sung-Hee Cho, Da Yong Lee
Environment International , 108522 (2024)

Three-dimensional label-free visualization of the interactions of PM2.5 with macrophages and epithelial cells using optical diffraction tomography
Wang Sik Lee, Inha Kang, Sung-Jin Yoon, Hyunjung Kim, Yugyeong Sim, Youngjun Park, Jinah Park, Jinyoung Jeong
Journal of Hazardous Materials 456 , 131678 (2023)

Combined effects of microplastics and benz[a]anthracene on cardiotoxicity in zebrafish (Danio rerio) larvae: Size matters
Yugyeong Sim, Hyun-Ju Cho, Jeong-Soo Lee, Wang Sik Lee, Hyunjung Kim, Jinyoung Jeong
Chemosphere 330 , 138723 (2023)

Differential particle and ion kinetics of silver nanoparticles in the lungs and biotransformation to insoluble silver sulfide
Soyeon Jeon, Wang Sik Lee, Kyung Seuk Song, Jiyoung Jeong, Sinuk Lee, Songyeon Kim, Gyuri Kim, Ji-Su Kim, Jinyoung Jeong, Wan-Seob Cho
Journal of Hazardous Materials 452 , 131223 (2023)

A Simple and Rapid Methicillin-Resistant Staphylococcus aureus (MRSA) Screening Test Using a Mannose-Binding Lectin (MBL)-Conjugated Gold Nanoparticle Probe
So Yeon Yi, Jinyoung Jeong, Wang Sik Lee, Jungsun Kwon, Kyungah Yoon, Kyoungsook Park
Journal of Microbiology and Biotechnology 33 , 698-705 (2023)

Antioxidants prevent particulate matter-induced senescence of lung fibroblasts
Sein Jin, Sung-Jin Yoon, Na-Young Jung, Wang Sik Lee, Jinyoung Jeong, Young-Jun Park, Wantae Kim, Doo-Byoung Oh, Jinho Seo
Heliyon 9 , e14179 (2023)

A review on the impacts of nanomaterials on neuromodulation and neurological dysfunction using a zebrafish animal model
Hyun-Ju Cho, Wang Sik Lee, Jinyoung Jeong, Jeong-Soo Lee
Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 261 , 109428 (2022)

Maternal exposure to polystyrene nanoplastics causes brain abnormalities in progeny
Bohyeon Jeong, Jeong Yeob Baek, Jahong Koo, Subin Park, Young-Kyoung Ryu, Kyoung-Shim Kim, Seungjae Zhang, ChiHye Chung, Rumeysa Dogan, Hyung-Seok Choi, Dahun Um, Tae-Kyung Kim, Wang Sik Lee, Jinyoung Jeong, Won-Ho Shin, Jae-Ran Lee, Nam-Soon Kim, Da Yong Lee
Journal of Hazardous Materials 426 , 127815 (2022)

Fluorescent Polypropylene Nanoplastics for Studying Uptake, Biodistribution, and Excretion in Zebrafish Embryos
Wang Sik Lee, Hyunjung Kim, Yugyeong Sim, Taejoon Kang, Jinyoung Jeong
ACS Omega 7 , 2467-2473 (2022)

Differential Clearance of Aβ Species from the Brain by Brain Lymphatic Endothelial Cells in Zebrafish
Yun-Mi Jeong, Jae-Geun Lee, Hyun-Ju Cho, Wang Sik Lee, Jinyoung Jeong, Jeong-Soo Lee
International Journal of Molecular Sciences 22 , 11883 (2021)

Biomimetic Nanopillar-Based Biosensor for Label-Free Detection of Influenza A Virus
Wang Sik Lee, Junhyoung Ahn, Sanghee Jung, Jaejong Lee, Taejoon Kang, Jinyoung Jeong
BioChip Journal 15 , 260-267 (2021)

3D Hierarchical Nanotopography for On-Site Rapid Capture and Sensitive Detection of Infectious Microbial Pathogens
Kyung Hoon Kim, Ahreum Hwang, Younseong Song, Wang Sik Lee, Jeong Moon, Jinyoung Jeong, Nam Ho Bae, Young Mee Jung, Jiyoung Jung, Seunghwa Ryu, Seok Jae Lee, Bong Gill Choi, Taejoon Kang, Kyoung G. Lee
ACS Nano 15 , 4777-4788 (2021)

Simple, rapid, and accurate malaria diagnostic platform using microfluidic-based immunoassay of Plasmodium falciparum lactate dehydrogenase
Wang Sik Lee, Taejoon Kang, Kyung Jin Kwak, Kyoungsook Park, So Yeon Yi, Ui Jin Lee, Yong Beom Shin, Jinyoung Jeong
Nano Convergence 7 (2020)

Effect of elastin‐like polypeptide incorporation on the adhesion maturation of mineral trioxide aggregates
Hyun‐Jung Kim, Wang Sik Lee, Jinyoung Jeong, Duck Su Kim, Seung‐Wuk Lee, Sun‐Young Kim
Journal of Biomedical Materials Research Part B: Applied Biomaterials 108 , 2847-2856 (2020)

Poly-γ-Glutamic Acid Complexed With Alum Induces Cross-Protective Immunity of Pandemic H1N1 Vaccine
Quyen Thi Nguyen, Chaewon Kwak, Wang Sik Lee, Jaemoo Kim, Jinyoung Jeong, Moon Hee Sung, Jihyun Yang, Haryoung Poo
Frontiers in Immunology 10 (2019)

Detection of Ampicillin-Resistant E. coli Using Novel Nanoprobe-Combined Fluorescence In Situ Hybridization
Wang Sik Lee, Soohyun Lee, Taejoon Kang, Choong-Min Ryu, Jinyoung Jeong
Nanomaterials 9 , 750 (2019)

FRET probe-based antibacterial susceptibility testing (F-AST) by detection of bacterial nucleases released by antibiotic-induced lysis
Kyoungsook Park, Jinyoung Jeong, So Yeon Yi, Wang Sik Lee, Yong Beom Shin
Biosensors and Bioelectronics 130 , 225-229 (2019)

Bioaccumulation of polystyrene nanoplastics and their effect on the toxicity of Au ions in zebrafish embryos
Wang Sik Lee, Hyun-Ju Cho, Eungwang Kim, Yang Hoon Huh, Hyo-Jeong Kim, Bongsoo Kim, Taejoon Kang, Jeong-Soo Lee, Jinyoung Jeong
Nanoscale 11 , 3173-3185 (2019)

The Relationship between Dissolution Behavior and the Toxicity of Silver Nanoparticles on Zebrafish Embryos in Different Ionic Environments
Wang Lee, Eungwang Kim, Hyun-Ju Cho, Taejoon Kang, Bongsoo Kim, Min Kim, Yong Kim, Nam Song, Jeong-Soo Lee, Jinyoung Jeong
Nanomaterials 8 , 652 (2018)

Fabrication of Pyrrole‐Based Electrochemical Biosensor Platform Using Nanoimprint Lithography
Junhyoung Ahn, Soongeun Kwon, Sanghee Jung, Wang Sik Lee, Jinyoung Jeong, Hyungjun Lim, Yong‐Beom Shin, JaeJong Lee
Advanced Materials Interfaces 5 (2018)

An Antibody-Immobilized Silica Inverse Opal Nanostructure for Label-Free Optical Biosensors
Wang Lee, Taejoon Kang, Shin-Hyun Kim, Jinyoung Jeong
Sensors 18 , 307 (2018)

Simple and rapid detection of bacteria using a nuclease-responsive DNA probe
Kyung Jin Lee, Wang Sik Lee, Ahreum Hwang, Jeong Moon, Taejoon Kang, Kyoungsook Park, Jinyoung Jeong
The Analyst 143 , 332-338 (2018)

In vivo toxicity assessment of angiogenesis and the live distribution of nano-graphene oxide and its PEGylated derivatives using the developing zebrafish embryo
Jinyoung Jeong, Hyun-Ju Cho, Mijin Choi, Wang Sik Lee, Bong Hyun Chung, Jeong-Soo Lee
Carbon 93 , 431-440 (2015)

LEE Wangsik

Engineering Core-Shell Nanomaterials

Exploring Cell Density Effects on Nanoparticle Uptake Using Bioprinted Gradients