Person | Adolphe Merkle Institute | Université de Fribourg

DRASLER Barbara

NCCR

Adolphe Merkle Institute Chemin des Verdiers 4 CH-1700 Fribourg Switzerland

Office:	B423
Email:	barbara.drasler@unifr.ch

Projects team

3D Tissue Models to Assess Hazards (Lung / Intestine / Skin)

Tissue-based 3D cell culture models mimic physiological and barrier properties of human skin, lung or…

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Hazard Assessment of Aerosolized Nanomaterials

Aerosolisation approaches for a direct and controlled exposure of nanomaterials on the cell surface

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Stimulation of cellular endocytosis for sensing and enhancing nanoparticle uptake

With the development of nanotechnology, nanoparticles ...

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Bioinspired Hyaluronic Acid-coated Gold Nanoparticles to Target Lung Cancer Cells

Hyaluronic acid coated gold nanoparticles with Doxorubicin

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Publications

In vitro approaches to assess the hazard of nanomaterials
Drasler Barbara, Sayre Phil, Steinhäuser Klaus Günter, Petri-Fink Alke, Rothen-Rutishauser Barbara
NanoImpact (2017)

Quantifying nanoparticle cellular uptake: which method is best?
Drasler Barbara, Vanhecke Dimitri, Rodriguez-Lorenzo Laura, Petri-Fink Alke, Rothen-Rutishauser Barbara
Nanomedicine (2017)

Corrigendum to “In vitro approaches to assess the hazard of nanomaterials” [NanoImpact 8, October 2017, 99–116]
Drasler Barbara, Sayre Phil, Steinhäuser Klaus Günter, Petri-Fink Alke, Rothen-Rutishauser Barbara
NanoImpact (2018)

Respiratory hazard assessment of combined exposure to complete gasoline exhaust and respirable volcanic ash in a multicellular human lung model at the air-liquid interface
Tomašek Ines, Horwell Claire J., Bisig Christoph, Damby David E., Comte Pierre, Czerwinski Jan, Petri-Fink Alke, Clift Martin J.D., Drasler Barbara, Rothen-Rutishauser Barbara
Environmental Pollution (2018)

Carbon nanodots: Opportunities and limitations to study their biodistribution at the human lung epithelial tissue barrier
Durantie Estelle, Barosova Hana, Drasler Barbara, Rodriguez-Lorenzo Laura, Urban Dominic A., Vanhecke Dimitri, Septiadi Dedy, Hirschi-Ackermann Liliane, Petri-Fink Alke, Rothen-Rutishauser Barbara
Biointerphases (2018)

Polydopamine/Transferrin Hybrid Nanoparticles for Targeted Cell-Killing
Hauser Daniel, Estermann Manuela, Milosevic Ana, Steinmetz Lukas, Vanhecke Dimitri, Septiadi Dedy, Drasler Barbara, Petri-Fink Alke, Ball Vincent, Rothen-Rutishauser Barbara
Nanomaterials (2018)

Single exposure to aerosolized graphene oxide and graphene nanoplatelets did not initiate an acute biological response in a 3D human lung model
Drasler Barbara, Kucki Melanie, Delhaes Flavien, Buerki-Thurnherr Tina, Vanhecke Dimitri, Korejwo Daria, Chortarea Savvina, Barosova Hana, Hirsch Cordula, Petri-Fink Alke, Rothen-Rutishauser Barbara, Wick Peter
Carbon (2018)

The in vivo effects of silver nanoparticles on terrestrial isopods, Porcellio scaber, depend on a dynamic interplay between shape, size and nanoparticle dissolution properties
Novak Sara, Romih Tea, Drašler Barbara, Birarda Giovanni, Vaccari Lisa, Ferraris Paolo, Sorieul Stephanie, Zieba Maciej, Sebastian Victor, Arruebo Manuel, Hočevar Samo B., Jemec Kokalj Anita, Drobne Damjana
The Analyst (2019)

Assessment of the potential for in-plume sulphur dioxide gas-ash interactions to influence the respiratory toxicity of volcanic ash
Tomašek Ines, Damby David E., Horwell Claire J., Ayris Paul M., Delmelle Pierre, Ottley Christopher J., Cubillas Pablo, Casas Ana S., Bisig Christoph, Petri-Fink Alke, Dingwell Donald B., Clift Martin J.D., Drasler Barbara, Rothen-Rutishauser Barbara
Environmental Research (2019)

Lipid nanoparticles biocompatibility and cellular uptake in a 3D human lung model
Magalhães Joana, Pinheiro Marina, Drasler Barbara, Septiadi Dedy, Petri-Fink Alke, Santos Susana G, Rothen-Rutishauser Barbara, Reis Salette
Nanomedicine (2019)

On the issue of transparency and reproducibility in nanomedicine
Leong Hon S., Butler Kimberly S., Brinker C. Jeffrey, Azzawi May, Conlan Steve, Dufés Christine, Owen Andrew, Rannard Steve, Scott Chris, Chen Chunying, Dobrovolskaia Marina A., Kozlov Serguei V., Prina-Mello Adriele, Schmid Ruth, Wick Peter, Caputo Fanny, Boisseau Patrick, Crist Rachael M., McNeil Scott E., Fadeel Bengt, Tran Lang, Hansen Steffen Foss, Hartmann Nanna B., Clausen Lauge P. W., Skjolding Lars M., Baun Anders, Ågerstrand Marlene, Gu Zhen, Lamprou Dimitrios A., Hoskins Clare, Huang Leaf, Song Wantong, Cao Huiliang, Liu Xuanyong, Jandt Klaus D., Jiang Wen, Kim Betty Y. S., Wheeler Korin E., Chetwynd Andrew J., Lynch Iseult, Moghimi Seyed Moein, Nel André, Xia Tian, Weiss Paul S., Sarmento Bruno, das Neves José, Santos Hélder A., Santos Luis, Mitragotri Samir, Little Steve, Peer Dan, Amiji Mansoor M., Alonso Maria José, Petri-Fink Alke, Balog Sandor, Lee Aaron, Drasler Barbara, Rothen-Rutishauser Barbara, Wilhelm Stefan, Acar Handan, Harrison Roger G., Mao Chuanbin, Mukherjee Priyabrata, Ramesh Rajagopal, McNally Lacey R., Busatto Sara, Wolfram Joy, Bergese Paolo, Ferrari Mauro, Fang Ronnie H., Zhang Liangfang, Zheng Jie, Peng Chuanqi, Du Bujie, Yu Mengxiao, Charron Danielle M., Zheng Gang, Pastore Chiara
Nature Nanotechnology (2019)

Publisher Correction: On the issue of transparency and reproducibility in nanomedicine
Leong Hon S., Butler Kimberly S., Brinker C. Jeffrey, Azzawi May, Conlan Steve, Dufès Christine, Owen Andrew, Rannard Steve, Scott Chris, Chen Chunying, Dobrovolskaia Marina A., Kozlov Serguei V., Prina-Mello Adriele, Schmid Ruth, Wick Peter, Caputo Fanny, Boisseau Patrick, Crist Rachael M., McNeil Scott E., Fadeel Bengt, Tran Lang, Hansen Steffen Foss, Hartmann Nanna B., Clausen Lauge P. W., Skjolding Lars M., Baun Anders, Ågerstrand Marlene, Gu Zhen, Lamprou Dimitrios A., Hoskins Clare, Huang Leaf, Song Wantong, Cao Huiliang, Liu Xuanyong, Jandt Klaus D., Jiang Wen, Kim Betty Y. S., Wheeler Korin E., Chetwynd Andrew J., Lynch Iseult, Moghimi Seyed Moein, Nel André, Xia Tian, Weiss Paul S., Sarmento Bruno, das Neves José, Santos Hélder A., Santos Luis, Mitragotri Samir, Little Steve, Peer Dan, Amiji Mansoor M., Alonso Maria José, Petri-Fink Alke, Balog Sandor, Lee Aaron, Drasler Barbara, Rothen-Rutishauser Barbara, Wilhelm Stefan, Acar Handan, Harrison Roger G., Mao Chuanbin, Mukherjee Priyabrata, Ramesh Rajagopal, McNally Lacey R., Busatto Sara, Wolfram Joy, Bergese Paolo, Ferrari Mauro, Fang Ronnie H., Zhang Liangfang, Zheng Jie, Peng Chuanqi, Du Bujie, Yu Mengxiao, Charron Danielle M., Zheng Gang, Pastore Chiara
Nature Nanotechnology (2019)

Publisher Correction: On the issue of transparency and reproducibility in nanomedicine
Leong Hon S., Butler Kimberly S., Brinker C. Jeffrey, Azzawi May, Conlan Steve, Dufès Christine, Owen Andrew, Rannard Steve, Scott Chris, Chen Chunying, Dobrovolskaia Marina A., Kozlov Serguei V., Prina-Mello Adriele, Schmid Ruth, Wick Peter, Caputo Fanny, Boisseau Patrick, Crist Rachael M., McNeil Scott E., Fadeel Bengt, Tran Lang, Hansen Steffen Foss, Hartmann Nanna B., Clausen Lauge P. W., Skjolding Lars M., Baun Anders, Ågerstrand Marlene, Gu Zhen, Lamprou Dimitrios A., Hoskins Clare, Huang Leaf, Song Wantong, Cao Huiliang, Liu Xuanyong, Jandt Klaus D., Jiang Wen, Kim Betty Y. S., Wheeler Korin E., Chetwynd Andrew J., Lynch Iseult, Moghimi Sayed Moein, Nel André, Xia Tian, Weiss Paul S., Sarmento Bruno, Neves José das, Santos Hélder A., Santos Luis, Mitragotri Samir, Little Steve, Peer Dan, Amiji Mansoor M., Alonso Maria José, Petri-Fink Alke, Balog Sandor, Lee Aaron, Drasler Barbara, Rothen-Rutishauser Barbara, Wilhelm Stefan, Acar Handan, Harrison Roger G., Mao Chuanbin, Mukherjee Priyabrata, Ramesh Rajagopal, McNally Lacey R., Busatto Sara, Wolfram Joy, Bergese Paolo, Ferrari Mauro, Fang Ronnie H., Zhang Liangfang, Zheng Jie, Peng Chuanqi, Du Bujie, Yu Mengxiao, Charron Danielle M., Zheng Gang, Pastore Chiara
Nature Nanotechnology (2019)

Immunotoxicity Testing – In Vitro Cell Culture Models
Rothen-Rutishauser Barbara, Drasler Barbara, Petri-Fink Alke
Interaction of Nanomaterials with the Immune System (2020)

Multicellular Human Alveolar Model Composed of Epithelial Cells and Primary Immune Cells for Hazard Assessment
Barosova Hana, Drasler Barbara, Petri-Fink Alke, Rothen-Rutishauser Barbara
Journal of Visualized Experiments (2020)

Impact of airborne particulate matter on skin: a systematic review from epidemiology to in vitro studies
Dijkhoff Irini M., Drasler Barbara, Karakocak Bedia Begum, Petri-Fink Alke, Valacchi Giuseppe, Eeman Marc, Rothen-Rutishauser Barbara
Particle and Fibre Toxicology (2020)

An Inflamed Human Alveolar Model for Testing the Efficiency of Anti-inflammatory Drugs in vitro
Drasler Barbara, Karakocak Bedia Begum, Tankus Esma Bahar, Barosova Hana, Abe Jun, Sousa de Almeida Mauro, Petri-Fink Alke, Rothen-Rutishauser Barbara
Frontiers in Bioengineering and Biotechnology (2020)

Increased Uptake of Silica Nanoparticles in Inflamed Macrophages but Not upon Co-Exposure to Micron-Sized Particles
Susnik Eva, Taladriz-Blanco Patricia, Drasler Barbara, Balog Sandor, Petri-Fink Alke, Rothen-Rutishauser Barbara
Cells (2020)

Patient-derived and artificial ascites have minor effects on MeT-5A mesothelial cells and do not facilitate ovarian cancer cell adhesion
Estermann Manuela, Huang Yen-Lin, Septiadi Dedy, Ritz Danilo, Liang Ching-Yeu, Jacob Francis, Drasler Barbara, Petri-Fink Alke, Heinzelmann-Schwarz Viola, Rothen-Rutishauser Barbara
PLOS ONE (2020)

Proteomic investigation of Zn-challenged rice roots reveals adverse effects and root physiological adaptation
Šimon Martin, Shen Zhi-Jun, Ghoto Kabir, Chen Juan, Liu Xiang, Gao Gui-Feng, Jemec Kokalj Anita, Novak Sara, Drašler Barbara, Zhang Jing-Ya, You Yan-Ping, Drobne Damjana, Zheng Hai-Lei
Plant and Soil (2020)

Understanding the Development, Standardization, and Validation Process of Alternative In Vitro Test Methods for Regulatory Approval from a Researcher Perspective
Bas Aurora, Burns Nicole, Gulotta Andrew, Junker James, Drasler Barbara, Lehner Roman, Aicher Lothar, Constant Samuel, Petri‐Fink Alke, Rothen‐Rutishauser Barbara
Small (2021)

Design of Perfused PTFE Vessel‐Like Constructs for In Vitro Applications
Estermann Manuela, Spiaggia Giovanni, Septiadi Dedy, Dijkhoff Irini Magdelina, Drasler Barbara, Petri‐Fink Alke, Rothen‐Rutishauser Barbara
Macromolecular Bioscience (2021)

Understanding nanoparticle endocytosis to improve targeting strategies in nanomedicine
Sousa de Almeida Mauro, Susnik Eva, Drasler Barbara, Taladriz-Blanco Patricia, Petri-Fink Alke, Rothen-Rutishauser Barbara
Chemical Society Reviews (2021)

Cellular Uptake of Silica and Gold Nanoparticles Induces Early Activation of Nuclear Receptor NR4A1
Sousa de Almeida Mauro, Taladriz-Blanco Patricia, Drasler Barbara, Balog Sandor, Yajan Phattadon, Petri-Fink Alke, Rothen-Rutishauser Barbara
Nanomaterials (2022)

A 3D multi-cellular tissue model of the human omentum to study the formation of ovarian cancer metastasis
Estermann Manuela, Coelho Ricardo, Jacob Francis, Huang Yen-Lin, Liang Ching-Yeu, Faia-Torres Ana Bela, Septiadi Dedy, Drasler Barbara, Karakocak Bedia Begum, Dijkhoff Irini Magdelina, Petri-Fink Alke, Heinzelmann-Schwarz Viola, Rothen-Rutishauser Barbara
Biomaterials (2023)

Comparing species-different responses in pulmonary fibrosis research: Current understanding of in vitro lung cell models and nanomaterials
Keshavan Sandeep, Bannuscher Anne, Drasler Barbara, Barosova Hana, Petri-Fink Alke, Rothen-Rutishauser Barbara
European Journal of Pharmaceutical Sciences (2023)

An inter-laboratory effort to harmonize the cell-delivered in vitro dose of aerosolized materials
Bannuscher Anne, Schmid Otmar, Drasler Barbara, Rohrbasser Alain, Braakhuis Hedwig M., Meldrum Kirsty, Zwart Edwin P., Gremmer Eric R., Birk Barbara, Rissel Manuel, Landsiedel Robert, Moschini Elisa, Evans Stephen J., Kumar Pramod, Orak Sezer, Doryab Ali, Erdem Johanna Samulin, Serchi Tommaso, Vandebriel Rob J., Cassee Flemming R., Doak Shareen H., Petri-Fink Alke, Zienolddiny Shanbeh, Clift Martin J.D., Rothen-Rutishauser Barbara
NanoImpact (2022)

DRASLER Barbara

3D Tissue Models to Assess Hazards (Lung / Intestine / Skin)

Hazard Assessment of Aerosolized Nanomaterials

Stimulation of cellular endocytosis for sensing and enhancing nanoparticle uptake

Bioinspired Hyaluronic Acid-coated Gold Nanoparticles to Target Lung Cancer Cells