Person | Adolphe Merkle Institute | Université de Fribourg

Taylor dispersion analysis and release studies of β-carotene-loaded PLGA nanoparticles and liposomes in simulated gastrointestinal fluids
Roman M. Fortunatus, Sandor Balog, Flávia Sousa, Dimitri Vanhecke, Barbara Rothen-Rutishauser, Patricia Taladriz-Blanco, Alke Petri-Fink
RSC Advances 15 , 1095-1104 (2025)

Engineering nanomaterials for glioblastoma nanovaccination
Fatima Hameedat, Bárbara B. Mendes, João Conniot, Leonardo D. Di Filippo, Marlus Chorilli, Avi Schroeder, João Conde, Flávia Sousa
Nature Reviews Materials (2024)

Immunostimulatory nanoparticles delivering cytokines as a novel cancer nanoadjuvant to empower glioblastoma immunotherapy
Flávia Sousa, Henry Lee, Mauro Almeida, Amelie Bazzoni, Barbara Rothen-Rutishauser, Alke Petri-Fink
Drug Delivery and Translational Research (2023)

Polymeric nanoparticles targeting Sialyl-Tn in gastric cancer: A live tracking under flow conditions
Francisca Diniz, Maria Azevedo, Flávia Sousa, Hugo Osório, Diana Campos, Paula Sampaio, Joana Gomes, Bruno Sarmento, Celso A. Reis
Materials Today Bio 16 , 100417 (2022)

Brain-Targeted Drug Delivery
Flávia Sousa
Pharmaceutics 14 , 1835 (2022)

Implantable and long-lasting drug delivery systems for cancer treatment
Catarina Pacheco, Ana Baião, Flávia Sousa, Bruno Sarmento
Long-Acting Drug Delivery Systems , 129-162 (2022)

Intratumoral VEGF nanotrapper reduces gliobastoma vascularization and tumor cell mass
Flávia Sousa, Ana Isabel Costa-Pereira, Andrea Cruz, Fábio Júnio Ferreira, Marcos Gouveia, José Bessa, Bruno Sarmento, Rui D.M. Travasso, Inês Mendes Pinto
Journal of Controlled Release 339 , 381-390 (2021)

Structural and functional analysis of broad pH and thermal stable protease from Penicillium aurantiogriseum URM 4622
José Manoel Wanderley Duarte Neto, Jônatas de Carvalho Silva, Flávia Sousa, Odete Sofia Lopes Gonçalves, Maria Carolina de Albuquerque Wanderley, Bruno Sarmento, Carolina de Albuquerque Lima, Maria Teresa Neves-Petersen, Ana Lúcia Figueiredo Porto
Preparative Biochemistry & Biotechnology 52 , 578-589 (2021)

In vitro model for predicting the access and distribution of drugs in the brain using hCMEC/D3 cells
Bárbara Sánchez-Dengra, Isabel González-Álvarez, Flavia Sousa, Marival Bermejo, Marta González-Álvarez, Bruno Sarmento
European Journal of Pharmaceutics and Biopharmaceutics 163 , 120-126 (2021)

Engineering the drug carrier biointerface to overcome biological barriers to drug delivery
Joel A. Finbloom, Flávia Sousa, Molly M. Stevens, Tejal A. Desai
Advanced Drug Delivery Reviews 167 , 89-108 (2020)

Prediction of the enhanced insulin absorption across a triple co-cultured intestinal model using mucus penetrating PLGA nanoparticles
Abdolelah Jaradat, Maria Helena Macedo, Flávia Sousa, Kenton Arkill, Cameron Alexander, Jonathan Aylott, Bruno Sarmento
International Journal of Pharmaceutics 585 , 119516 (2020)

The solid progress of nanomedicine
João Pedro Martins, José das Neves, María de la Fuente, Christian Celia, Helena Florindo, Nazende Günday-Türeli, Amirali Popat, José Luis Santos, Flávia Sousa, Ruth Schmid, Joy Wolfram, Bruno Sarmento, Hélder A. Santos
Drug Delivery and Translational Research 10 , 726-729 (2020)

Effective intracellular delivery of bevacizumab via PEGylated polymeric nanoparticles targeting the CD44v6 receptor in colon cancer cells
Ana Baião, Flávia Sousa, Ana Vanessa Oliveira, Carla Oliveira, Bruno Sarmento
Biomaterials Science 8 , 3720-3729 (2020)

In situ inflammatory-regulated drug-loaded hydrogels for promoting pelvic floor repair
Menglu Qin, Jing Jin, Qimanguli Saiding, Yi Xiang, Yong Wang, Flávia Sousa, Bruno Sarmento, Wenguo Cui, Xinliang Chen
Journal of Controlled Release 322 , 375-389 (2020)

Chitosan-based nanomedicine for brain delivery: Where are we heading?
Catarina Pacheco, Flávia Sousa, Bruno Sarmento
Reactive and Functional Polymers 146 , 104430 (2020)

Enhanced anti-angiogenic effect of bevacizumab in PLGA nanoparticles on glioblastoma treatment upon intranasal administration

conference-poster (2019)

Blood-brain barrier receptors and transporters: an insight on their function and how to exploit them through nanotechnology
Rui Pedro Moura, Cláudia Martins, Soraia Pinto, Flávia Sousa, Bruno Sarmento
Expert Opinion on Drug Delivery 16 , 271-285 (2019)

Recent advance of erythrocyte-mimicking nanovehicles: From bench to bedside
Jielai Yang, Fei Wang, Yong Lu, Jin Qi, Lianfu Deng, Flávia Sousa, Bruno Sarmento, Xiangyang Xu, Wenguo Cui
Journal of Controlled Release 314 , 81-91 (2019)

Enhanced anti-angiogenic effects of bevacizumab in glioblastoma treatment upon intranasal administration in polymeric nanoparticles
Flávia Sousa, Harkiranpreet Kaur Dhaliwal, Florence Gattacceca, Bruno Sarmento, Mansoor M. Amiji
Journal of Controlled Release 309 , 37-47 (2019)

Development and characterization of lipid-polymeric nanoparticles for oral insulin delivery
Débora Sgorla, Anna Lechanteur, Andreia Almeida, Flávia Sousa, Eduardo Melo, Élcio Bunhak, Rubiana Mainardes, Najeh Khalil, Osvaldo Cavalcanti, Bruno Sarmento
Expert Opinion on Drug Delivery 15 , 213-222 (2018)

Alginate-Based Delivery Systems For Bevacizumab Local Therapy: In Vitro Stuctural Features And Release Properties
Natália Noronha Ferreira, Bruno Leonardo Caetano, Fernanda Isadora Boni, Flávia Sousa, Marina Magnani, Bruno Sarmento, Beatriz Stringhetti Ferreira Cury, Maria Palmira Daflon Gremião
Journal of Pharmaceutical Sciences 108 , 1559-1568 (2018)

Functionalizing PLGA and PLGA Derivatives for Drug Delivery and Tissue Regeneration Applications
Cláudia Martins, Flávia Sousa, Francisca Araújo, Bruno Sarmento
Advanced Healthcare Materials 7 , 1701035 (2018)

Fab-conjugated PLGA nanoparticles effectively target cancer cells expressing human CD44v6
Patrick J. Kennedy, Flavia Sousa, Daniel Ferreira, Carla Pereira, Marika Nestor, Carla Oliveira, Pedro L. Granja, Bruno Sarmento
Acta Biomaterialia 81 , 208-218 (2018)

Carcinoembryonic antigen-targeted nanoparticles potentiate the delivery of anticancer drugs to colorectal cancer cells
Inês Pereira, Flávia Sousa, Patrick Kennedy, Bruno Sarmento
International Journal of Pharmaceutics 549 , 397-403 (2018)

Biophysical, photochemical and biochemical characterization of a protease from Aspergillus tamarii URM4634
Osmar Soares da Silva, Jônatas de Carvalho Silva, Elizane Melo de Almeida, Flávia Sousa, Odete Sofia Lopes Gonçalves, Bruno Sarmento, Maria Teresa Neves-Petersen, Tatiana Souza Porto
International Journal of Biological Macromolecules 118 , 1655-1666 (2018)

Nanoparticles provide long-term stability of bevacizumab preserving its antiangiogenic activity
Flávia Sousa, Andrea Cruz, Inês Mendes Pinto, Bruno Sarmento
Acta Biomaterialia 78 , 285-295 (2018)

Incorporation of beads into oral films for buccal and oral delivery of bioactive molecules
Pedro M. Castro, Flávia Sousa, Rui Magalhães, Victor Manuel Pizones Ruiz-Henestrosa, Ana M.R. Pilosof, Ana Raquel Madureira, Bruno Sarmento, Manuela E. Pintado
Carbohydrate Polymers 194 , 411-421 (2018)

Extraction and characterisation of cellulose nanocrystals from pineapple peel
Ana Madureira, Tugba Atatoprak, Duygu Cabuk, Flavia Sousa, Manuela Pintado, Robert C. Pullar
International Journal of Food Studies , 24-33 (2018)

Polyester-based nanoparticles for the encapsulation of monoclonal antibodies
Flávia Sousa, Pedro Fonte, Andreia Cruz, Patrick J. Kennedy, Inês Mendes Pinto, Bruno Sarmento
Methods in Molecular Biology , 239-253 (2018)

Therapeutic Monoclonal Antibodies Delivery for the Glioblastoma Treatment
Flávia Sousa, Rui P. Moura, Elias Moreira, Cláudia Martins, Bruno Sarmento
Therapeutic Proteins and Peptides , 61-80 (2018)

Poly(Lactic-co-Glycolic) Acid: Functionalizing PLGA and PLGA Derivatives for Drug Delivery and Tissue Regeneration Applications (Adv. Healthcare Mater. 1/2018)
Cláudia Martins, Flávia Sousa, Francisca Araújo, Bruno Sarmento
Advanced Healthcare Materials 7 , 1870002 (2018)

Polyester-based nanoparticles for delivery of therapeutic proteins
Pedro Fonte, Flávia Sousa, Bruno Sarmento
Methods in Molecular Biology , 255-274 (2018)

Nanoparticles for the delivery of therapeutic antibodies: Dogma or promising strategy?
Flávia Sousa, Pedro Castro, Pedro Fonte, Patrick J. Kennedy, Maria Teresa Neves-Petersen, Bruno Sarmento
Expert Opinion on Drug Delivery 14 , 1163-1176 (2017)

A new paradigm for antiangiogenic therapy through controlled release of bevacizumab from PLGA nanoparticles
Flávia Sousa, Andrea Cruz, Pedro Fonte, Inês Mendes Pinto, Maria Teresa Neves-Petersen, Bruno Sarmento
Scientific Reports 7 (2017)

Biophysical study of bevacizumab structure and bioactivity under thermal and pH-stresses
Flávia Sousa, Bruno Sarmento, Maria Teresa Neves-Petersen
European Journal of Pharmaceutical Sciences 105 , 127-136 (2017)

Development and validation of a rapid reversed-phase HPLC method for the quantification of monoclonal antibody bevacizumab from polyester-based nanoparticles
Flávia Sousa, Virgínia M.F. Gonçalves, Bruno Sarmento
Journal of Pharmaceutical and Biomedical Analysis 142 , 171-177 (2017)

Cell-based in vitro models for nasal permeability studies
Flávia Sousa, Pedro Castro
Concepts and Models for Drug Permeability Studies , 83-100 (2016)

How to overcome the limitations of current insulin administration with new non-invasive delivery systems

journal-article (2015)

Oral strips as breakthrough tools for oral delivery of proteins/peptides
Pedro M. Castro, Pedro Fonte, Flávia Sousa, Ana Raquel Madureira, Bruno Sarmento, Manuela E. Pintado
Journal of Controlled Release 211 , 63-73 (2015)

A stability study perspective of the effect of freeze-drying using cryoprotectants on the structure of insulin loaded into PLGA nanoparticles
Pedro Fonte, Sandra Soares, Flávia Sousa, Ana Costa, Vítor Seabra, Salette Reis, Bruno Sarmento
Biomacromolecules 15 , 3753-3765 (2014)

Office:	B226
Phone:	9426
Email:	flavia.sousa@unifr.ch
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SOUSA Flavia