The physicochemical properties of nanoparticles and experimental methodology of exposure influences cellular assays. The cellular response is dosage dependent and knowledge of accurate dosing and metrics is required. Nanoparticle dosimetry and computational particokinetic models become essential in in vitro nanoparticle toxicology assays and our aim is to develop and deploy the concept of particokinetics for a wide range of particle systems, including nanoparticles from both industrial production lines and academic laboratories. For this, we use the combination of mathematical modelling, instrumental analytics and experimentation.
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Understanding selectivity of metabolic labelling and click-targeting in multicellular environments as a route to tissue selective drug delivery
Tan Angel, Liu Qingtao, Septiadi Dedy, Chu Shuiling, Liu Tianqing, Richards Sarah-Jane, Rothen-Rutishauser Barbara, Petri-Fink Alke, Gibson Matthew I., Boyd Ben J.
Journal of Materials Chemistry B (2021)
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