Trafficking of Nanomaterials
Uptake, intracellular trafficking, and exocytosis are processes that affect cytotoxicity, cell behavior, and the therapeutic efficacy of nanomaterials.
With nanomedicines on the rise it is crucial to understand the interactions between nanomaterials and biological systems. Many studies focus on the in vivo biokinetics and biodistribution of nanomaterials to determine the potential long term effects presented by the material and its accumulation inside cells. This project focuses on the fate of biopersistent nanoparticles (e.g. trafficking from endosomes to lysosomes, dissolution, exocytosis and dilution during cell division).
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Nanomaterials Versus Ambient Ultrafine Particles: An Opportunity to Exchange Toxicology Knowledge
Stone Vicki, Miller Mark R., Clift Martin J.D., Elder Alison, Mills Nicholas L., Møller Peter, Schins Roel P.F., Vogel Ulla, Kreyling Wolfgang G., Alstrup Jensen Keld, Kuhlbusch Thomas A.J., Schwarze Per E., Hoet Peter, Pietroiusti Antonio, De Vizcaya-Ruiz Andrea, Baeza-Squiban Armelle, Teixeira João Paulo, Tran C. Lang, Cassee Flemming R.
Environmental Health Perspectives (2017)Revealing the Role of Epithelial Mechanics and Macrophage Clearance during Pulmonary Epithelial Injury Recovery in the Presence of Carbon Nanotubes
Septiadi Dedy, Abdussalam Wildan, Rodriguez-Lorenzo Laura, Spuch-Calvar Miguel, Bourquin Joël, Petri-Fink Alke, Rothen-Rutishauser Barbara
Advanced Materials (2018)The crux of positive controls - Pro-inflammatory responses in lung cell models
Bisig Christoph, Voss Carola, Petri-Fink Alke, Rothen-Rutishauser Barbara
Toxicology in Vitro (2019)Single exposure to aerosolized graphene oxide and graphene nanoplatelets did not initiate an acute biological response in a 3D human lung model
Drasler Barbara, Kucki Melanie, Delhaes Flavien, Buerki-Thurnherr Tina, Vanhecke Dimitri, Korejwo Daria, Chortarea Savvina, Barosova Hana, Hirsch Cordula, Petri-Fink Alke, Rothen-Rutishauser Barbara, Wick Peter
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