Person | Adolphe Merkle Institute | Université de Fribourg

AWASTHI Saurabh

Alumni

Group Leader, BioPhysics

Adolphe Merkle Institute Chemin des Verdiers 4 CH-1700 Fribourg Switzerland

Office:	C046
Phone:	+41 26 300 9542
Email:	saurabh.awasthi@unifr.ch
	0000-0002-7243-5578

Projects team

Amyloids

Characterization of amyloid-forming peptides and oligomers.

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Solid-State Nanopores

Single-protein analysis using solid-state nanopores.

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Fabrication of Nanopores

Fabrication of synthetic nanopores in custom sizes and materials.

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Publications

The Aggregation Continuum of α-Synuclein and Its Relevance to Brain Aging
Anika Rana, Tejas Nikam, Bhargavi Sreepathi, Shubhini A. Saraf, Saurabh Awasthi
ACS Chemical Neuroscience (2025)

Selective and Controllable Trapping of Single Proteins in Nanopores using Reversible Covalent Bonds
Yuanjie Li, Saurabh Awasthi, Peng Liu, Anna Protopopova, Michael Mayer
not found (2025)

Pneumolysin nanopores with 20 nm inner diameter to characterize the size and shape of Tau oligomers
Anasua Mukhopadhyay, Wachara Chanakul, Yu-Noel Larpin, Saurabh Awasthi, Anna D. Protopopova, René Köffel, Alessandro Ianiro, Michael Mayer
not found (2025)

Large and Stable Nanopores Formed by Complement Component 9 for Characterizing Single Folded Proteins
Wachara Chanakul, Anasua Mukhopadhyay, Saurabh Awasthi, Anna D. Protopopova, Alessandro Ianiro, Michael Mayer
ACS Nano (2025)

Fluorescence-Based Monitoring of Early-Stage Aggregation of Amyloid-β, Amylin Peptide, Tau, and α-Synuclein Proteins
Yuanjie Li, Saurabh Awasthi, Louise Bryan, Rachel S. Ehrlich, Nicolo Tonali, Sandor Balog, Jerry Yang, Norbert Sewald, Michael Mayer
ACS Chemical Neuroscience (2024)

Simultaneous Determination of the Size and Shape of Single α-Synuclein Oligomers in Solution
Saurabh Awasthi, Cuifeng Ying, Jiali Li, Michael Mayer
ACS Nano (2023)

Simultaneous Determination of Size and Shape of Single α-Synuclein Oligomers in Solution
Saurabh Awasthi, Cuifeng Ying, Jiali Li, Michael Mayer
preprint (2023)

Site-Specific C-Terminal Fluorescent Labeling of Tau Protein
Louise Bryan, Saurabh Awasthi, Yuanjie Li, Peter Niraj Nirmalraj, Sandor Balog, Jerry Yang, Michael Mayer
ACS Omega (2022)

Site-specific C-terminal fluorescent labeling of Tau protein
Louise Bryan, Saurabh Awasthi, Yuanjie Li, Peter Niraj Nirmalraj, Sandor Balog, Jerry Yang, Michael Mayer
preprint (2022)

Interrogating conformational dynamics of single-proteins in a plasmonic hotspot
Edona Karakaci, Cuifeng Ying, Saurabh Awasthi, Esteban Bermuúdez-Urenña, Michael Mayer
Biophysical Journal 121 , 182a (2022)

Sortase A-mediated site-specific labeling of Tau protein
Yuanjie Li, Saurabh Awasthi, Louise Bryan, Peter N. Nirmalraj, Michael Mayer
Biophysical Journal 121 , 353a (2022)

Single‐particle characterization of tau oligomers in solution
Saurabh Awasthi, Michael Mayer
Alzheimer's & Dementia 17 (2021)

Watching Single Unmodified Enzymes at Work

journal-article (2021)

Polymer Coatings to Minimize Protein Adsorption in Solid‐State Nanopores
Saurabh Awasthi, Pongsatorn Sriboonpeng, Cuifeng Ying, Jared Houghtaling, Ivan Shorubalko, Sanjin Marion, Sebastian James Davis, Laura Sola, Marcella Chiari, Aleksandra Radenovic, Michael Mayer
Small Methods (2020)

Protein Trapping in a Nanopore Well
Jiali Li, Cuifeng Ying, Saurabh Awasthi, Trevor Kalkus, Mitu C. Acharjee, Michael Mayer
Biophysical Journal 118 , 157a (2020)

Nordihydroguaiaretic acid prevents glycation induced structural alterations and aggregation of albumin
Saurabh Awasthi, R. Preethy, N.T. Saraswathi
International Journal of Biological Macromolecules (2019)

Formation of Single Nanopores with Diameters of 20–50 nm in Silicon Nitride Membranes Using Laser-Assisted Controlled Breakdown
Cuifeng Ying, Jared Houghtaling, Olivia M. Eggenberger, Anirvan Guha, Peter Nirmalraj, Saurabh Awasthi, Jianguo Tian, Michael Mayer
ACS Nano 12 , 11458-11470 (2018)

Troxerutin imparts preservative effects on albumin by preventing Maillard reaction-mediated early and advanced glycation modification
Saurabh Awasthi, Aravind Ravi, N.T. Saraswathi
Journal of Biomolecular Structure and Dynamics (2017)

Elucidating the molecular interaction of sinigrin, a potent anticancer glucosinolate from cruciferous vegetables with bovine serum albumin: effect of methylglyoxal modification
Saurabh Awasthi, N.T. Saraswathi
Journal of Biomolecular Structure and Dynamics (2016)

Advanced glycation end products induce differential structural modifications and fibrillation of albumin
Saurabh Awasthi, Kamatchi Sankaranarayanan, N.T. Saraswathi
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy (2016)

Vanillin restrains non-enzymatic glycation and aggregation of albumin by chemical chaperone like function
Saurabh Awasthi, N.T. Saraswathi
International Journal of Biological Macromolecules (2016)

Sinigrin, a major glucosinolate from cruciferous vegetables restrains non-enzymatic glycation of albumin
Saurabh Awasthi, N.T. Saraswathi
International Journal of Biological Macromolecules (2016)

Carbonyl scavenging and chemical chaperon like function of essential amino acids attenuates non-enzymatic glycation of albumin
Saurabh Awasthi, N. T. Saraswathi
RSC Advances (2016)

Non-enzymatic glycation mediated structure–function changes in proteins: case of serum albumin
Saurabh Awasthi, N. T. Saraswathi
RSC Advances (2016)

Advanced Glycation-Modified Human Serum Albumin Evokes Alterations in Membrane and Eryptosis in Erythrocytes
Saurabh Awasthi, S. K. Gayathiri, R. Ramya, R. Duraichelvan, A. Dhason, N. T. Saraswathi
Applied Biochemistry and Biotechnology (2015)

Advanced Glycation End Products Modulate Structure and Drug Binding Properties of Albumin
Saurabh Awasthi, N. Arul Murugan, N. T. Saraswathi
Molecular Pharmaceutics (2015)

Crystal structure of Alanine-Copper(II) complex to understand the mechanism of salt induced prebiotic oligomerization of amino acids
Saurabh Awasthi, Saraswathi N.T.
Crystal Research and Technology 50 , 304-311 (2015)

Silybin, a flavonolignan from milk thistle seeds, restrains the early and advanced glycation end product modification of albumin
Saurabh Awasthi, N. T. Saraswathi
RSC Advances 5 , 87660-87666 (2015)

Comparative Studies of Plumeria Species for their Phytochemical and Antifungal Properties Against Citrus sinensis Pathogens
G. Sibi, Saurabh Awasthi, K. Dhananjaya, H. Mallesha, K.R. Ravikumar
International Journal of Agricultural Research 7 , 324-331 (2012)

Insilico studies of daidzein and genistein with human estrogen receptor α
K. Dhananjaya, G. Sibi, H. Mallesha, K.R. Ravikumar, Saurabh Awasthi
Asian Pacific Journal of Tropical Biomedicine 2 , S1747-S1753 (2012)

AWASTHI Saurabh

Amyloids

Solid-State Nanopores

Fabrication of Nanopores