Person | Adolphe Merkle Institute | Université de Fribourg

TASKOVA Maria

Alumni

BioPhysics

Adolphe Merkle Institute Chemin des Verdiers 4 CH-1700 Fribourg Switzerland

Office:	C046
Phone:	+41 26 300 9539
Email:	maria.taskova@unifr.ch
Website:	https://pubmed.ncbi.nlm.nih.gov/?term=Taskova+M&filter=datesearch.y_10
	0000-0002-9727-2496

Projects team

Oligonucleotide therapeutics

Multi-modified oligonucleotide therapeutics for targeted intracellular delivery.

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Publications

Natural and Modified Oligonucleotide Sequences Show Distinct Strand Displacement Kinetics and These Are Affected Further by Molecular Crowders
Ivana Domljanovic, Alessandro Ianiro, Curzio Rüegg, Michael Mayer, Maria Taskova
Biomolecules 12 , 1249 (2022)

p38γ and p38δ as biomarkers in the interplay of colon cancer and inflammatory bowel diseases
Pilar Fajardo, Maria Taskova, Miguel A. Martín‐Serrano, Jonas Hansen, Sofie Slott, Anna K. Jakobsen, Marie‐Louise Wibom, Beñat Salegi, Alberto Muñoz, Antonio Barbachano, Arpita Sharma, John Mark Gubatan, Aida Habtezion, Juan J. Sanz‐Ezquerro, Kira Astakhova, Ana Cuenda
Cancer Communications 42 , 897-901 (2022)

Multi-Functionalized Heteroduplex Antisense Oligonucleotides for Targeted Intracellular Delivery and Gene Silencing in HeLa Cells
Mauro Sousa de Almeida, Barbara Rothen-Rutishauser, Michael Mayer, Maria Taskova
Biomedicines 10 , 2096 (2022)

Enhanced target cell specificity and uptake of lipid nanoparticles using RNA aptamers and peptides
Roslyn M Ray, Anders Højgaard Hansen, Maria Taskova, Bernhard Jandl, Jonas Hansen, Citra Soemardy, Kevin V Morris, Kira Astakhova
Beilstein Journal of Organic Chemistry 17 , 891-907 (2021)

Optical and theoretical study of strand recognition by nucleic acid probes
Ivana Domljanovic, Maria Taskova, Pâmella Miranda, Gerald Weber, Kira Astakhova
Communications Chemistry 3 (2020)

Solid-Phase Hybridization Assay for Detection of Mutated Cancer DNA by Fluorescence
Maria Taskova, Kira Astakhova
Methods in Molecular Biology , 37-44 (2020)

Fluorescent Oligonucleotides with Bis(prop-2-yn-1-yloxy)butane-1,3-diol Scaffold Rapidly Detect Disease-Associated Nucleic Acids
Maria Taskova, Kira Astakhova
Bioconjugate Chemistry 30 , 3007-3012 (2019)

Control of LDL Uptake in Human Cells by Targeting the LDLR Regulatory Long Non-coding RNA BM450697
Roslyn M. Ray, Anders Højgaard Hansen, Sofie Slott, Maria Taskova, Kira Astakhova, Kevin V. Morris
Molecular Therapy - Nucleic Acids 17 , 264-276 (2019)

Lipid Nanoparticles for Delivery of Therapeutic RNA Oligonucleotides
Keith Henry Moss, Petya Popova, Sine R. Hadrup, Kira Astakhova, Maria Taskova
Molecular Pharmaceutics 16 , 2265-2277 (2019)

Studies of Impending Oligonucleotide Therapeutics in Simulated Biofluids
Ivana Domljanovic, Anders Højgaard Hansen, Lykke H. Hansen, Janne Kudsk Klitgaard, Maria Taskova, Kira Astakhova
Nucleic Acid Therapeutics 28 , 348-356 (2018)

“Clicking” Gene Therapeutics: A Successful Union of Chemistry and Biomedicine for New Solutions
Kira Astakhova, Roslyn Ray, Maria Taskova, Jesper Uhd, Annika Carstens, Kevin Morris
Molecular Pharmaceutics 15 , 2892-2899 (2018)

Dihydropyridine Fluorophores Allow for Specific Detection of Human Antibodies in Serum
Ivana Domljanovic, Elisabeth Rexen Ulven, Trond Ulven, Rasmus P. Thomsen, Anders H. Okholm, Jørgen Kjems, Anne Voss, Maria Taskova, Kira Astakhova
ACS Omega 3 , 7580-7586 (2018)

Synthetic Nucleic Acid Analogues in Gene Therapy: An Update for Peptide-Oligonucleotide Conjugates
Maria Taskova, Anna Mantsiou, Kira Astakhova
ChemBioChem 18 , 1671-1682 (2017)

New Fluorescent Nanoparticles for Ultrasensitive Detection of Nucleic Acids by Optical Methods
Mads Westergaard Mulberg, Maria Taskova, Rasmus P. Thomsen, Anders H. Okholm, Jørgen Kjems, Kira Astakhova
ChemBioChem 18 , 1599-1603 (2017)

Amplification-free liquid biopsy by fluorescence approach

TechConnect Briefs (2017)

Tandem Oligonucleotide Probe Annealing and Elongation To Discriminate Viral Sequence
Maria Taskova, Jesper Uhd, Laura Miotke, Matthew Kubit, John Bell, Hanlee P. Ji, Kira Astakhova
Analytical Chemistry 89 , 4363-4366 (2017)

Antisense Oligonucleotides Internally Labeled with Peptides Show Improved Target Recognition and Stability to Enzymatic Degradation
Maria Taskova, Charlotte S. Madsen, Knud J. Jensen, Lykke Haastrup Hansen, Birte Vester, Kira Astakhova
Bioconjugate Chemistry 28 , 768-774 (2017)

Environmentally sensitive molecular probes reveal mutations and epigenetic 5-methyl cytosine in human oncogenes
M. Taskova, M. C. Barducci, K. Astakhova
Organic & Biomolecular Chemistry 15 , 5680-5684 (2017)

TASKOVA Maria

Oligonucleotide therapeutics